Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Flow reactor networks for integrated synthesis of active pharmaceutical ingredients

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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach a...

Continuous flow multi-step organic synthesis

The multi-step synthesis of complex organic compounds from simpler precursors is one of the outstanding accomplishments and ongoing challenges of synthetic organic chemistry. Through the development and invention of synthesis strategies, methods and technologies, increasingly complex molecules can be assembled with designed structures and functions for a variety of medicinal, agrochemical and m...

Recrystallization of Active Pharmaceutical Ingredients

Heterogeneous Nucleation of Active Pharmaceutical Ingredients on Polymers: Applications in Continuous Pharmaceutical Manufacturing

In this thesis work, we aimed to explore crystallization processes for small molecule API compounds based on engineered polymer surfaces that could be used in continuous manufacturing. First, we identified a library of polymers that can be used and selected PVA as the model polymer based on its solution and film properties. We also illustrated a rational approach for designing and fabricating P...